Figure 6.

VsEP waveforms. VsEP measurements were made in wild-type (WT), α9 KO, α9/10 KO, and α7/9 KO mice. VsEP waveforms shown were produced in response to the maximum level stimulation (+6 dB re:1 g/msec). The first three peaks are marked in the first pair of responses representing p1, n1, and p2 (n1 is marked but not labeled here). The WT animals produced responses with normal morphology and moderate variation in amplitudes and latencies. WT waveforms generally had well-formed, highly reproducible P1 and P2 response peaks. The WT response pair marked with an asterisk has unusually low amplitudes and was the only example of such poor amplitude in WT animals. The remaining four examples of WT waveforms demonstrate the typical variation seen among normal animals. VsEP waveforms of the α7/9 KO group (bottom five trace pairs labeled α7/9 KO) also had well-formed responses comparable to those of WT animals. In contrast, response waveforms for both α9 and α9/10 animals were far more variable, where amplitudes ranged from those comparable to normal WT animals to very low amplitudes, including absent or virtually absent responses in α9 KOs (e.g., traces pairs 2 and 5 of α9 KO group). Examples of such poorly formed responses from α9 KO and α9/10 KO animals are shown as the middle 10 response trace-pairs (labels α9 KO and α9/10 KO). Responses of many α9 KO and α9/10 KO animals exhibited peaks with unusually short latency and duration. Examples of this can be seen, especially in α9/10 KO animals.