TABLE 2.
VsEP Thresholds and Amplitudes1
| Genotype | Threshold (dB re:1 g/msec) | p1n1 (μV) | p2n1 (μV) |
|---|---|---|---|
| WT | −11.18 ± 2.58 (44) | 0.998 ± 0.344 (44) | 1.041 ± 0.391 (43) |
| α9 KO | −7.66 ± 5.30 (28)3 | 0.665 ± 0.333 (26)3 | 0.771 ± 0.389 (25)2 |
| α9/10 KO | −7.30 ± 4.31 (15)3 | 0.387 ± 0.161 (15)3 | 0.554 ± 0.186 (14)3 |
| α7/9 KO | −10.80 ± 2.36 (20) | 0.924 ± 0.213 (20) | 0.829 ± 0.234 (20) |
| α7 KO | −10.07 ± 1.60 (14) | 1.114 ± 0.360 (14) | 1.196 ± 0.395 (14) |
| α10 KO | −10.33 ± 1.92 (18) | 1.172 ± 0.316 (18) | 1.187 ± 0.311 (18) |
Values are mean ± SD (n); thresholds and amplitudes (p1n1 and p2n1) were obtained at the highest stimulus level (+6 dB re:1 g/msec). Statistical tests for thresholds (ANOVA, F5,33 = 5.865, P = 6.3 × 10−5; LSD: α9 KO: P = 2.9 × 10−5, α9/10 KO: P = 1.8 × 10−4), Response amplitudes at the highest stimulus level (MANOVA, F10,256 = 7.709, P = 8.9 × 10−11, LSD: p1n1: α9 KO, P = 4.9 × 10−5, α9/10 KO, P = 2.43 × 10−9; p2n1: α9 KO, P = 0.0022, α9/10 KO, P = 1.0 × 10−5), and response amplitudes at the three highest levels (0, +3, and +6 dB re:1 g/msec: rmMANOVA, F10,250 = 6.53, P = 5.7 × 10−9; LSD: α9 KO, p1n1: P = 2.08 × 10−4; p2n1: P = 0.003; LSD: α9/10 KO, p1n1: P = 1.22 × 10−8; p2n1: P = 1.0 × 10−6) were significantly reduced in the α9 KO and α9/10 KO. Amplitudes for the α9/10 KOs tended to be less than those of α9 KOs (+6 dB re:1 g/msec, MANOVA, F10,256 = 7.709, P = 8.9 × 10−11, LSD: p1n1: P = 0.0067).
P < 0.003.
P < 0.001.