Table I.
Occurrence of Merkel cell carcinoma, 2006–2015
| All | Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Category | N (%) | IR (95% CI) per 100,000 persons | APC* | N (%) | IR (95% CI) per 100,000 persons | APC* | N (%) | IR (95% CI) per 100,000 persons | APC* |
| Overall, ages ≥50 y | 19,722 (100.0) | 2.1 (2.1–2.2) | 2.3† | 12,615 (100.0) | 3.3 (3.2–3.3) | 2.5† | 7107 (100.0) | 1.3 (1.3–1.3) | 1.3 |
| Age, y | |||||||||
| 50–54 | 504 (2.6) | 0.2 (0.2–0.2) | 0.1 | 315 (2.5) | 0.3 (0.3–0.3) | 1.0 | 189 (2.7) | 0.2 (0.1–0.2) | ‡ |
| 55–59 | 991 (5.0) | 0.5 (0.5–0.5) | −1.0 | 609 (4.8) | 0.6 (0.6–0.7) | −2.9† | 382 (5.4) | 0.4 (0.3–0.4) | 2.1 |
| 60–64 | 1529 (7.8) | 0.9 (0.9–1.0) | 0 | 1001 (7.9) | 1.2 (1.2–1.3) | 0.8 | 528 (7.4) | 0.6 (0.6–0.7) | −1.5 |
| 65–69 | 2225 (11.3) | 1.7 (1.6–1.8) | 3.3† | 1478 (11.7) | 2.4 (2.3–2.5) | 3.1 | 747 (10.5) | 1.1 (1.0–1.2) | 3.5† |
| 70–74 | 2743 (13.9) | 2.8 (2.7–2.9) | 4.1† | 1863 (14.8) | 4.2 (4.0–4.4) | 4.5† | 880 (12.4) | 1.7 (1.6–1.8) | 2.9† |
| 75–79 | 3463 (17.6) | 4.6 (4.4–4.7) | 1.7 | 2315 (18.4) | 7.0 (6.8–7.3) | 2.1† | 1148 (16.2) | 2.7 (2.5–2.9) | 0.3 |
| 80–84 | 3681 (18.7) | 6.4 (6.2–6.6) | 2.7† | 2402 (19.0) | 10.4 (10.0–10.8) | 3.1† | 1279 (18.0) | 3.7 (3.5–3.9) | 1.2 |
| ≥85 | 4586 (23.3) | 8.2 (7.9–8.4) | 2.3† | 2632 (20.9) | 14.2 (13.7–14.8) | 2.4† | 1954 (27.5) | 5.2 (5.0–5.4) | 1.3 |
| Stage | |||||||||
| Localized | 10,790 (61.9) | 1.2 (1.1–1.2) | 2.1† | 6586 (59.1) | 1.7 (1.7–1.8) | 2.3† | 4204 (66.8) | 0.8 (0.8–0.8) | 1.4 |
| Regional | 4795 (27.5) | 0.5 (0.5–0.5) | 3.3† | 3224 (28.9) | 0.8 (0.8–0.8) | 3.3† | 1571 (25.0) | 0.3 (0.3–0.3) | 2.8 |
| Distant | 1850 (10.6) | 0.2 (0.2–0.2) | 5.0† | 1333 (12.0) | 0.3 (0.3–0.4) | 5.9† | 517 (8.2) | 0.1 (0.1–0.1) | 0.9 |
| Race/ethnicity§ | |||||||||
| Non-Hispanic white | 18,368 (95.0) | 2.5 (2.4–2.5) | 2.7† | 11,933 (96.3) | 3.8 (3.8–3.9) | 2.9† | 6435 (92.7) | 1.5 (1.5–1.5) | 1.6 |
| Non-Hispanic black | 248 (1.3) | 0.3 (0.3–0.3) | 3.3 | 112 (0.9) | 0.4 (0.3–0.4) | ‡ | 136 (2.0) | 0.3 (0.2–0.3) | ‡ |
| Hispanic, all races | 721 (3.7) | 1.1 (1.0–1.2) | −0.1 | 351 (2.8) | 1.3 (1.1–1.4) | 0.3 | 370 (5.3) | 1.0 (0.9–1.1) | −0.6 |
| Anatomic site | |||||||||
| Head and neck | 8426 (47.6) | 0.9 (0.9–0.9) | 2.4† | 5515 (49.2) | 1.5 (1.5–1.5) | 2.4† | 2911 (44.9) | 0.5 (0.5–0.5) | 1.6 |
| Trunk | 1889 (10.7) | 0.2 (0.2–0.2) | 1.0 | 1372 (12.2) | 0.3 (0.3–0.4) | 2.0 | 517 (8.0) | 0.1 (0.1–0.1) | −2.4 |
| Upper extremity | 4637 (26.2) | 0.5 (0.5–0.5) | 2.6† | 2918 (26.0) | 0.7 (0.7–0.8) | 2.4† | 1719 (26.5) | 0.3 (0.3–0.3) | 2.3 |
| Lower extremity | 2743 (15.5) | 0.3 (0.3–0.3) | 2.1† | 1405 (12.5) | 0.4 (0.3–0.4) | 3.0† | 1338 (20.6) | 0.2 (0.2–0.3) | 1.3 |
APC, Annual percent change; CI, confidence interval; IR, incidence rate.
*
A positive number means incidence rates are increasing, and a negative number indicates incidence rates are decreasing over the specified time period.
†
The APC is significantly different from zero (P < .05).
‡
The statistic could not be calculated.
§
Other race/ethnicity combinations (non-Hispanic Asian/Pacific Islander, non-Hispanic American Indian/Alaska Native, non-Hispanic multiple races) excluded due to small case counts.