Table 1.

Top 10 upregulated KEGG gene sets in GSK-3α KI (vs WT) mouse heart.

	GS follow link to MSigDB	SIZE	ES	NES	NOM p-val	FDR q-val
1	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	45	0.76	2.52	0	0
2	KEGG_PPAR_SIGNALING_PATHWAY	60	0.66	2.31	0	0.001
3	KEGG_GLYCINE_SERINE_AND THREONINE_METABOLISM	28	0.74	2.22	0.001	0.001
4	KEGG_CYSTEINE_AND_METHIONINE_METABOLISM	29	0.72	2.15	0	0.002
5	KEGG_SPLICEOSOME	90	0.48	1.77	0	0.131
6	KEGG_PHENYLALANINE_METABOLISM	16	0.65	1.75	0.019	0.135
7	KEGG_TRYPTOPHAN METABOLISM	33	0.56	1.74	0.006	0.131
8	KEGG_BASAL_TRANSCRIPTION_FACTORS	30	0.57	1.72	0.012	0.131
9	KEGG_PROTEASOME	42	0.53	1.72	0.011	0.123
10	KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM	42	0.54	1.71	0.001	0.115

The PPAR signaling pathway is most significantly enriched among energy metabolism-related gene sets in the hearts of GSK-3α knock-in (KI) mice compared to wild-type (WT) mice at three months of age, a time point before the development of cardiomyopathy in GSK-3α KI mice.