Table 2:
Changes in Measures of Tobacco Exposure
| Placebo/Nicotine # of Subjects | Placebo Mean (SD) | Nicotine Mean (SD) | P-Value* | P-Value** | |
|---|---|---|---|---|---|
| Cigarettes Per Day (Survey) | |||||
| Baseline | 67/70 | 8.04 (4.59) | 8.66 (4.71) | ||
| Visit 2 | 32/43 | 5.03 (4.69) | 3.48 (3.29) | 0.009 | 0.022 |
| Visit 5 | 37/35 | 3.51 (2.69) | 2.37 (1.78) | 0.038 | 0.042 |
| Visit 6 | 41/47 | 2.85 (3.50) | 2.43 (2.22) | 0.041 | 0.108 |
| Cotinine (ng/mL) | |||||
| Baseline | 59/65 | 108.45 (62.65) | 117.59 (77.40) | ||
| Visit 2 | 38/47 | 89.87 (62.35) | 88.09 (54.66) | 0.143 | 0.131 |
| Visit 5 | 30/27 | 99.19 (62.20) | 103.64 (66.91) | 0.435 | 0.492 |
| Visit 6 | 26/39 | 85.48 (58.84) | 87.97 (56.36) | 0.290 | 0.229 |
| Exhaled CO (ppm) | |||||
| Baseline | 66/70 | 10.80 (7.28) | 11.39 (8.34) | ||
| Visit 2 | 33/44 | 7.94 (6.77) | 9.14 (7.01) | 0.883 | 0.637 |
| Visit 5 | 37/36 | 8.43 (7.33) | 7.25 (5.23) | 0.961 | 0.959 |
| Visit 6 | 40/46 | 5.50 (5.42) | 6.7 (7.4) | 0.754 | 0.907 |
*
Analysis of change scores for participants with follow-up data (completer analyses) by two-sample t-test assuming unequal variances and no adjustment for potential confounders.
**
Analysis of change scores for participants with follow-up data (completer analyses) by linear regression with adjustment for site and motivation to quit smoking.