Figure 10b.

Metastatic clear cell RCC with enteritis in a 55-year-old woman who underwent checkpoint inhibition therapy. The patient developed abdominal pain and high-grade diarrhea after completion of a second cycle of combination therapy with ipilimumab and nivolumab. Coronal reconstructions of a nonenhanced CT examination reveal dilatation of proximal small bowel loops filled with oral contrast material (*), with fluid-filled nondistended loops of the distal small bowel (white arrow). Note the fluid-filled cecum (yellow arrow in b) in the right lower quadrant. Small-bowel biopsy results confirmed findings consistent with immunomodulatory enteritis.