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. 2019 Aug 2;14(8):e0215708. doi: 10.1371/journal.pone.0215708

Fig 1. Illustration detailing the immunoglobulin G capture assay (G capture) and the double antigen binding assay (DABA).

Fig 1

The G Capture solid phase (cross hatched) is coated with rabbit anti-human gamma FC to capture G from the clinical sample in the first step of the assay. After washing, conjugate is applied and specific antibody (Y) revealed by ZIKA virus NS1 antigen (ZKVNS1Ag) labelled with horseradish peroxidase (HRPO; Z *, standard). The DABA solid-phase is coated with ZKVNS1Ag to capture antibody to NS1Ag of any class. After washing, conjugate is applied and bound antibody (Y) revealed by ZKV NS1Ag labelled with HRPO as above.