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. 2019 Jul 23;15(7):e1007960. doi: 10.1371/journal.ppat.1007960

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© 2019 Ma et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Comparison of the ligand-binding domain (LBD) of DAF-12 of Haemonchus contortus (Hc-DAF-12) with that of Ac-DAF-12 from Ancylostoma caninum, using the following parameters: sequence length, root-mean-square deviation (RMSD), structural distance measure (SDM) and Q-score. (B) Activation of Hc-DAF-12 and Ac-DAF-12 by (25S)-Δ7-DA) in a luciferase reporter assay. The effects of 10 μM of (25S)-Δ7-DA on (C) larval exsheathment and (D) larval development. The effect of (25S)-Δ7-DA on larval development is both (E) dose- and (F) time- dependent. An error bar indicates a standard deviation (SD; four replicates). Statistical significance is indicated with one or more asterisks (*P < 0.05, **P < 0.01, ***P < 0.001, using Student’s t-test).