Table 2:

Reported Barriers to Adherence

Barriers to Adherence	Child/Adolescent Report N=132 Number (%)	Parent/Caregiver Report N =138 Number (%)
At least one barrier to adherence	89 (67%)	77 (56%)*
At least one logistic issuea	81 (61%)	64 (46%)*
At least one regimen issueb	38 (29%)*	20 (14%)*
At least one child factorc	46 (35%)*	34 (25%)
At least one disclosure issued	16 (12%)*	20(14%)
Child mental statee	11 (8%)	-
Caregiver mental statee	-	5 (4%)

^a“couldn’t get medications- drugstore did not have supply”; “didn’t refill”; “forgot”; “scheduling interferes with lifestyle”; “multiple caregivers”; “were away from home”; “were busy with other things”; “had a change in daily routine”; “fell asleep or slept through dose time”; “ran out of pills”

^b“taste, can’t get it down, spits up”; “side effects, toxicity”; “had too many pills to take”; “wanted to avoid side effects”; “felt like the medication was toxic or harmful”; “had problems taking pills as directed, for example on an empty stomach”

^c“child refuses”; “child had intercurrent illness”; “child felt sick or ill”; “child felt good”

^d“concerns about disclosure” (Parent/Caregiver report only); “did not want others to notice medication”

^e“felt depressed or overwhelmed”

^*One-tailed P-value <.05 for association with Log (RNA) viral load by multivariate censored regression adjusted for age at study entry, primary caregiver (biological parent vs. others) and child knowledge of HIV diagnosis by name. Age at study entry was a significant covariate (positive association) in all multivariate models.