Fig. 1.

Sirt3 expression in human AD brain. Sirt3 mRNA levels were analyzed in four brain regions. a Fold changes were compared in AD (n = 16) with those in CN cases (n = 11) which were set at 1. Sirt3 protein levels were quantified by ELISA. They were normalized with total protein (pg/μg). Sirt3 levels in CN, MCI, and AD groups were shown in b MTG, c SFG, d PVC, and e ENT. Data were reported mean ± SEM. AD Alzheimer’s disease, MCI mild cognitive impairment, CN cognitive normal controls, MTG middle temporal gyrus, SFG superior frontal gyrus, PVC primary visual cortex, ENT entorhinal cortex. *p < 0.05 and ***p < 0.001, compared to CN group