Fig. 5.

Oligo Aβ-42 induced an increase in total tau and Ac-tau and a decrease in Sirt3 in hTau primary neurons. Primary cortical neurons from newborn hTau mice were treated with various doses of oligo Aβ-42 for 24 h. a A representativeWestern blot of total tau (multiple bands ranging from 50 to 64 kDa), Ac-tau, and Sirt3 proteins was shown. b Total tau, c Ac-tau, and d Sirt3 levels were normalized with β-actin, an internal control. N = 6 per group; *p < 0.05 and **p < 0.01