. Author manuscript; available in PMC: 2020 Aug 2.

Published in final edited form as: J Proteome Res. 2019 Jul 1:10.1021/acs.jproteome.9b00185. doi: 10.1021/acs.jproteome.9b00185

Table 4.

Significant metabolites identified by GC-MS and LC-MS in HCC-N vs. ADJ-N liver tissues.

Metabolite	Mode	M_mi (Da)	RT (min.)	HCC-N vs. ADJ-N
				Whole population			AS			AA			EA
				p-value	FDR^†	FC	p-value	FDR^†	FC	p-value	FDR^†	FC	p-value	FDR^†	FC
fumaric acid	EI	116.01	11.2	2.72 E-09	2.88 E-07	↓−3.8	0.00211	0.11830	↓−2.6	0.00004	0.00217	↓−6.7	0.00001	0.00122	↓−4.3
malic acid	EI	134.02	13.1	1.15 E-07	5.52 E-06	↓−3.2	0.06400	0.50041	↓−1.8	0.00037	0.01228	↓−3.1	0.00002	0.00169	↓−4.0
succinic acid	EI	118.02	10.7	1.92 E-10	2.80 E-08	↓−2.9	0.00483	0.16747	↓−2.4	2.37E-06	0.00025	↓−3.6	0.00022	0.00954	↓−3.3
glucose	EI	180.06	18.1	2.30 E-06	0.00006	↓−2.8	0.03068	0.39253	↓−2.5	0.00114	0.02523	↓−4.2	0.00375	0.06199	↓−2.2
lactic acid	EI	90.03	6.6	0.00039	0.00409	↑+1.3	0.00071	0.05139	↑+1.4	0.41617	0.99999	↑+1.4	0.21269	0.78597	↑+1.2
hypoxanthine	EI	136.03	16.7	0.00497	0.02847	↑+1.6	0.04964	0.48374	↑+2.6	0.19531	0.78501	↑+1.8	0.44452	0.99999	↑+1.2
hypoxanthine	ESI−	136.03	0.6	0.01060	0.04336	↑+1.9	0.01038	0.14321	↑+3.3	0.15320	0.54342	↑+1.9	0.99807	0.99999	↑+1.3
xanthosine	EI	284.07	24.4	1.95 E-06	0.00006	↓−2.9	0.30885	0.99999	↓−1.7	0.00406	0.07082	↓−2.8	0.00002	0.00156	↓−3.9
xanthosine	ESI−	284.07	0.6	0.00003	0.00030	↓−4.1	0.32362	0.99999	↓−3.1	0.00360	0.05202	↓−4.4	0.00237	0.05550	↓−4.0
adenosine monophosphate	EI	347.06	27.1	0.00008	0.00115	↓−1.8	0.06100	0.49899	↓−1.8	0.01610	0.18028	↓−2.1	0.02881	0.23563	↓−1.6
adenosine monophosphate	ESI−	347.06	0.6	0.00100	0.00589	↓−2.6	0.05909	0.38933	↓−2.5	0.07575	0.36520	↓−3.5	0.17217	0.60745	↓−1.8
propionyl carnitine	ESI+	217.13	0.6	1.75 E-06	0.00004	↓−5.3	0.00034	0.01806	↓−6.5	0.00154	0.03235	↓−4.5	0.07789	0.54289	↓−5.0
linoleic acid	ESI−	280.23	8.8	0.00003	0.00031	↓−2.0	0.02878	0.24500	↓−1.4	0.00326	0.05029	↓−3.9	0.07603	0.34681	↓−1.5
PC(34:2)	ESI+	495.33	8.8	0.00067	0.00530	↓−2.1	0.14583	0.86099	↓−1.4	0.01737	0.17488	↓−2.5	0.15721	0.83788	↓−2.0
PC(38:3)	ESI+	811.60	10.3	0.00311	0.01969	↑+3.7	0.28471	0.99999	↑+5.5	0.00134	0.02888	↑+5.9	0.95680	0.99999	↑+1.4
PC(36:1)	ESI+	787.60	10.4	2.39 E-06	0.00005	↑+1.9	0.00694	0.10500	↑+1.7	0.00011	0.00699	↑+2.2	0.13370	0.75426	↑+1.8
PC(38:2)	ESI+	813.62	10.5	0.00092	0.00698	↑+1.6	0.00483	0.08333	↑+3.0	0.03028	0.26524	↑+1.8	0.89013	0.99999	↑+1.5
glycerol-3-phosphate	ESI−	172.01	0.6	3.05 E-06	0.00006	↓−3.9	0.10341	0.61322	↓−1.7	0.00083	0.02246	↓−6.5	0.00173	0.04690	↓−4.9
glycerylphosphoryl ethanolamine	ESI−	215.05	0.6	0.00023	0.00165	↓−2.9	0.11243	0.64653	↓−1.9	0.02312	0.18281	↓−4.5	0.04236	0.26761	↓−2.9
glycerophospho choline	ESI+	257.10	0.7	5.86 E-06	0.00011	↓−3.7	0.02022	0.22227	↓−3.6	0.00233	0.04207	↓−5.6	0.00957	0.17291	↓−3.5
coenzyme Q10	ESI+	862.68	12.4	0.00015	0.00153	↓−2.8	0.53056	0.99999	↓−1.6	0.00267	0.04506	↓−4.2	0.01850	0.24819	↓−2.9

^†

FDRs <10% are marked in bold