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Effect of EC359 on LIFR mediated transcription in TNBC cells. BT-549 (A) and MDA-MB-231 (B) cells stably expressing STAT3-luc reporter were serum starved for 24 h, pretreated with EC359 (50 nM) for 1 h and then stimulated with indicated concentrations of LIF, CTF1, OSM, CNTF (n=3). Reporter activity was measured after 24 h. C, Effect of EC359 (100 nM) treatment (12 h) on STAT3 targeted genes was measured using RT-qPCR analysis (n=3). ** P<0.01, *** P<0.001, ****p<0.0001
