Table 1.
Characteristics of Participants by Liver Fibrosis Scores Among Men 40 Years and Older, NHANES 2001–2010
| Overall | APRI | FIB-4 | NFS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Normal | Abnormala | Normal | Abnormal | Normal | Abnormal | ||||
| Unweighted Participants | 6,705 | 6,541 | 164 | 6,319 | 386 | 6,139 | 566 | ||
| Age group, % (95% CI) | |||||||||
| 40 – 49 years | 38.0 (36.2–39.9) |
37.9 (36.1–39.8) |
42.4 (32.3–53.2) |
39.0 (37.2–40.9) |
11.6 (7.3–17.7) |
40.0 (38.1–41.9) |
5.2 (3.8–7.1) |
||
| 50 – 59 years | 31.1 (29.4–32.8) |
31.1 (29.5–32.7) |
28.6 (19.1–40.3) |
31.6 (30.0–33.4) |
15.3 (10.5–21.7) |
32.0 (30.3–33.8) |
14.4 (10.5–19.5) |
||
| 60 – 69 years | 17.4 (16.5–18.4) |
17.4 (16.4–18.4) |
18.9 (13.8–25.3) |
17.3 (16.3–18.3) |
20.2 (15.5–25.9) |
16.8 (15.8–17.9) |
27.8 (23.4–32.6) |
||
| 70 – 79 years | 9.6 (9.0–10.3) |
9.7 (9.0–10.4) |
6.5 (3.7–11.1) |
9.0 (8.4–9.7) |
25.2 (21.1–29.7) |
8.2 (7.6–8.9) |
32.8 (29.0–36.7) |
||
| ≥80 years | 3.9 (3.5–4.4) |
3.9 (3.5–4.4) |
3.7 (2.0–6.5) |
3.0 (2.6–3.5) |
27.8 (23.7–32.3) |
3.0 (2.6–3.4) |
19.7 (17.0–22.8) |
||
| Race/ethnicity, % (95% CI) | |||||||||
| White (non-Hispanic) | 77.1 (74.5–79.7) |
77.3 (74.7–79.9) |
67.4 (57.4–77.4) |
77.2 (74.6–79.7) |
76.4 (71.0–81.9) |
77.0 (74.2–79.5) |
79.8 (75.4–83.6) |
||
| Black (non-Hispanic) | 8.6 (7.3–9.8) |
8.5 (7.2–9.7) |
14.4 (8.6–20.1) |
8.5 (7.3–9.7) |
10.6 (7.3–13.8) |
8.6 (7.4–9.9) |
8.3 (6.2–11.0) |
||
| Mexican-American/Other Hispanic | 9.6 (7.7–11.5) |
9.5 (7.6–11.4) |
12.5 (6.5–18.6) |
9.7 (7.8–11.6) |
7.1 (4.1–10.1) |
9.8 (8.0–11.9) |
6.6 (4.8–9.0) |
||
| Other | 4.7 (3.8–5.6) |
4.7 (3.7–5.6) |
5.7 (0.7–10.7) |
4.7 (3.7–5.6) |
5.9 (2.7–9.1) |
4.7 (3.8–5.7) |
5.4 (3.5–8.1) |
||
| Education level, % (95% CI) | |||||||||
| Less than 9th grade | 7.4 (6.5–8.2) |
7.3 (6.4–8.1) |
11.0 (5.9–16.2) |
7.1 (6.3–7.9) |
14.3 (10.7–17.9) |
6.9 (6.1–7.8) |
15.0 (11.3–19.6) |
||
| 9–11th grade (includes 12th grade, no diploma) | 10.2 (9.2–11.3) |
10.1 (9.0–11.1) |
18.5 (10.3–26.7) |
10.1 (9.0–11.1) |
15 (10.1–19.9) |
10.1 (9.1–11.3) |
11.6 (9.2–14.6) |
||
| High school graduate/GED or equivalent | 25.2 (23.8–26.6) |
25.0 (23.6–26.4) |
33.1 (24.7–41.6) |
25.2 (23.8–26.6) |
24.6 (18.6–30.6) |
25.5 (23.9–26.6) |
24.8 (21.0–29.0) |
||
| Some college or associates degree | 27.4 (26.0–28.9) |
27.5 (26.1–29.0) |
22.4 (14.4–30.4) |
27.6 (26.2–29.1) |
21.8 (16.0–27.7) |
27.4 (26.0–29.0) |
27.3 (21.5–34.1) |
||
| College graduate or above | 29.8 (27.6–32.0) |
30.1 (27.9–32.3) |
14.9 (7.2–22.6) |
30.0 (27.7–32.2) |
24.3 (18.1–30.5) |
30.3 (28.0–32.6) |
21.3 (16.9–26.4) |
||
| Drinking status, % (95% CI) | |||||||||
| Non-drinker or non-heavy drinker | 91.2 (90.3–92.1) |
91.6 (90.8–92.5) |
70.2 (62.3–78.1) |
91.4 (90.5–92.3) |
85.7 (81.4–90.1) |
91.0 (90.0–91.9) |
94.2 (91.6–96.0) |
||
| Heavy drinker | 8.8 (7.9–9.7) |
8.4 (7.5–9.2) |
29.8 (21.9–37.7) |
8.6 (7.7–9.5) |
14.3 (9.9–18.6) |
9.0 (8.1–10.0) |
5.8 (4.0–8.4) |
||
| Smoking history, % (95% CI) | |||||||||
| Never | 41.7 (39.7–43.6) |
42.1 (40.1–44.1) |
23.9 (14.6–33.3) |
41.9 (39.9–43.9) |
35.2 (29.7–40.7) |
42.1 (40.0–44.1) |
35.3 (31.1–39.8) |
||
| Ever | 58.3 (56.4–60.3) |
57.9 (55.9–59.9) |
76.1 (66.7–85.4) |
58.1 (56.1–60.1) |
64.8 (59.3–70.3) |
57.9 (55.9–60.0) |
64.7 (60.2–68.9) |
||
| BMI category, % (95% CI) | |||||||||
| Normal/overweight (<30 kg/m2) | 65.4 (63.7–67.2) |
65.5 (63.8–67.3) |
62.0 (52.9–71.1) |
65.3 (63.5–67.1) |
69.1 (63–75.2) |
67.4 (65.6–69.1) |
32.5 (28.8–36.4) |
||
| Obese (≥30 kg/m2) | 34.6 (32.8–36.3) |
34.5 (32.7–36.2) |
38.0 (28.9–47.1) |
34.7 (32.9–36.5) |
30.9 (24.8–37.0) |
32.6 (30.9–34.4) |
67.5 (63.6–71.2) |
||
| Diabetes status, % (95% CI) | |||||||||
| No diabetes | 63.5 (62.1–65.0) |
63.6 (62.2–65.0) |
61.9 (52.8–71.0) |
64.0 (62.5–65.4) |
51.7 (44–59.5) |
65.9 (64.4–67.3) |
24.5 (20.6–28.9) |
||
| At risk for diabetes | 22.5 (21.4–23.7) |
22.6 (21.4–23.8) |
17.5 (9.6–25.3) |
22.4 (21.2–23.7) |
24.8 (19.2–30.4) |
22.3 (21.1–23.6) |
25.4 (21.2–30.1) |
||
| Controlled diabetes | 5.8 (5.0–6.6) |
5.7 (4.9–6.6) |
7.7 (2.9–12.5) |
5.5 (4.7–6.3) |
12.5 (7.0–18.0) |
4.5 (3.8–5.4) |
26.7 (22.1–32.0) |
||
| Uncontrolled diabetes | 8.2 (7.3–9.1) |
8.1 (7.2–9.0) |
12.9 (6.1–19.7) |
8.1 (7.2–9.0) |
10.9 (7.4–14.4) |
7.3 (6.4–8.2) |
23.4 (19.1–28.3) |
||
| Self-reported liver disease, % (95% CI) | |||||||||
| Never | 95.2 (94.5–95.8) |
95.6 (95.0–96.2) |
75.7 (64.7–84.1) |
95.6 (94.9–96.2) |
85.1 (78.8–89.8) |
95.4 (94.6–96.0) |
92.4 (88.4–95.1) |
||
| Ever | 4.8 (4.2–5.5) |
4.4 (3.8–5.0) |
24.3 (15.9–35.3) |
4.4 (3.8–5.1) |
14.9 (10.2–21.2) |
4.6 (4.0–5.4) |
7.6 (4.9–11.6) |
||
| HCV status, % (95% CI) | |||||||||
| HCV negative | 96.7 (96.0–97.3) |
97.4 (96.7–97.9) |
65.3 (55.6–74.0) |
97.1 (96.4–97.6) |
86.2 (80.4–90.4) |
96.7 (96.0–97.3) |
96.1 (93.4–97.7) |
||
| HCV infected | 3.3 (2.7–4.0) |
2.6 (2.1–3.3) |
34.7 (26.0–44.4) |
2.9 (2.4–3.6) |
13.8 (9.6–19.6) |
3.3 (2.7–4.0) |
4.0 (2.3–6.6) |
||
| HBV status, % (95% CI) | |||||||||
| Negative | 92.2 (91.2–93.0) |
92.4 (91.5–93.3) |
79.2 (70.0–86.1) |
92.4 (91.4–93.3) |
85.6 (79.8–89.9) |
92.3 (91.3–93.2) |
90.1 (86.6–92.7) |
||
| Current or previous HBV infected | 7.8 (7.0–8.8) |
7.6 (6.7–8.5) |
20.8 (13.9–30.0) |
7.6 (6.7–8.6) |
14.4 (10.1–20.2) |
7.7 (6.8–8.7) |
9.9 (7.3–13.4) |
||
| Chronic HBV infected | 0.5 (0.3–0.7) |
0.5 (0.3–0.7) |
1.2 (3.5–4.0) |
0.5 (0.3–0.7) |
0.5 (0.2–1.7) |
0.5 (0.3–0.7) |
0.3 (0.1–1.2) |
||
a
Cutpoint for abnormal liver fibrosis score equates to advanced fibrosis (APRI >1, FIB-4 >2.67 and NFS >0.676).