Table 2:
Estimates of Hemodynamic and Metabolic Parameters before and after Weight Loss
| Number of studies (n) | Weighted Mean Pre WL | Mean Difference Following WL | 95% CI | p value | I2 (%) | |
|---|---|---|---|---|---|---|
| Rest | ||||||
| Heart rate (min−1) | 8 (93) | 76 | −9 | −11.7 to −5.7 | <0.001 | 57* |
| Mean arterial pressure (mmHg) | 7 (81) | 104 | −7 | −11.3 to −3.3 | <0.001 | 41 |
| Oxygen consumption (ml/min) | 3 (35) | 362 | −85 | −111 to −60 | <0.001 | 0 |
| Right atrial pressure (mmHg) | 3 (27) | 5 | −2.4 | −4.8 to −0.1 | 0.04 | 81* |
| Mean pulmonary artery pressure (mmHg) | 4 (60) | 23 | −5.2 | −8.1 to −2.2 | 0.001 | 45 |
| Pulmonary wedge pressure (mmHg) | 6 (76) | 12 | −3.2 | −5.0 to −1.4 | <0.001 | 40 |
| Cardiac output (l/min) | 8 (93) | 6.4 | −0.6 | −0.8 to −0.5 | <0.001 | 0 |
| Arterial-venous O2 difference (ml/ml) | 3 (35) | 4.6 | −0.4 | −0.9 to −0.01 | 0.04 | 0 |
| Exercise | ||||||
| Heart rate (min−1) | 5 (61) | 119 | −4 | −7.8 to +0.2 | 0.07 | 23 |
| Mean arterial pressure (mmHg) | 4 (49) | 124 | −13 | −21.6 to −5.2 | 0.001 | 26 |
| Oxygen consumption (ml/min) | 3 (35) | 1237 | −231 | −361 to −100 | <0.001 | 0 |
WL, weight loss. P value reflects the change with weight loss, (I2) reflects the heterogeneity for the change in each parameter with weight loss
*
heterogeneity p value<0.05