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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Mol Cancer Res. 2019 May 21:molcanres.0286.2019. doi: 10.1158/1541-7786.MCR-19-0286

Figure 5. Modified INSM1 promoter-driven oncolytic adenovirus (CRAd-HS4-INSM1-2xNRSE-∆24E1A-IRES-HSV-tk) suppresses neuroendocrine tumor cell growth (70).

Figure 5.

(A) INSM1 non-expressing cell lines, including lung adeno-squamous carcinoma (NCI-H596) and large cell lung carcinoma (NCI-H460), and INSM1-expressing cell lines such as SCLC (NCI-H69), carcinoid (UMC-11) and large cell lung carcinoma (NCI-H1155) were evaluated without or with virus (MOI = 50:1) at different GCV concentrations (μM). The oncolytic virus exhibits basal-killing efficiency due to virus replication in the absence of GCV, in contrast to efficient killing when GCV concentration increased. (B) Responsive killing with a constant GCV (50 μM) and incremental MOI was observed in INSM- expressing cells (UMC-11, NCI-H69 and NCI-H1155), while no effect was observed in INSM1 non-expressing cells (NCI-H596 and NCI-H460).