Table 1.
VDBP genetic variability in subject population by race/ethnicity and samples available for this study
| A. Number of individual subjects (% of total individuals within group) | |||||
|---|---|---|---|---|---|
| B. Number of annually collected serum samples (% of represented genotypes within group) | |||||
| C. Samples collected when subjects were meeting the vitD RDA (normalized to >25 IU/kg) | |||||
| VDBP genotype or haplotype | All subjects | African-American | Caucasian | Hispanic | |
| 1F/1F | A. | 33 (27%) | 30 (75%) | 0 (0%) | 3 (6%) |
| B. | 84 (25%) | 75 (74%) | – | 9 (6%) | |
| C. | 32 | 30 | – | 2 | |
| 1S/1F | A. | 25 (20%) | 6 (15%) | 6 (18%) | 13 (26%) |
| B. | 72 (22%) | 17 (17%) | 15 (17.6%) | 40 (27%) | |
| C. | 24 | 7 | 11 | 6 | |
| 1S/1S | A. | 23 (19%) | 1 (2.5%) | 10 (30.5%) | 12 (24%) |
| B. | 60 (18%) | 2 (2%) | 23 (27%) | 35 (24%) | |
| C. | 18 | 0 | 14 | 4 | |
| 1S/2 | A. | 24 (19.5%) | 1 (2.5%) | 10 (30.5%) | 13 (26%) |
| B. | 68 (20%) | 1 (1%) | 27 (31.8%) | 40 (27%) | |
| C. | 25 | 0 | 13 | 12 | |
| 1F/2 | A. | 13 (10.5%) | 2 (5%) | 3 (9%) | 8 (16%) |
| B. | 36 (11%) | 6 (6%) | 10 (11.8%) | 20 (14%) | |
| C. | 14 | 3 | 4 | 7 | |
| 2/2 | A. | 5 (4%) | 0 (0%) | 4 (12%) | 1 (2%) |
| B. | 13 (4%) | – | 10 (11.8%) | 3 (2%) | |
| C. | 1 | – | 1 | 0 | |
| All genotypes | A. | 123 subjects | 40 | 33 | 50 |
| B. | 333 | 101 | 85 | 147 | |
| C. | 114 (34%) | 40 (40%) | 43 (51%) | 31 (21%) | |
| 1F allelea (rs7041-T/rs4588-C) | A. | 71 (58%) | 38 (95%) | 9 (27%) | 24 (48%) |
| B. | 192 (58%) | 98 (97%) | 25 (29%) | 69 (47%) | |
| C. | 70 | 40 | 15 | 15 | |
| 1S alleleb (rs7041-G/rs4588-C) | A. | 72 (59%) | 8 (20%) | 26 (79%) | 38 (76%) |
| B. | 200 (60%) | 20 (20%) | 65 (76%) | 115 (78%) | |
| C. | 67 | 7 | 38 | 22 | |
| 2 allelec (rs7041-T/rs4588-A) | A. | 42 (34%) | 3 (8%) | 17 (52%) | 22 (44%) |
| B. | 117 (35%) | 7 (7%) | 47 (55%) | 63 (43%) | |
| C. | 40 | 3 | 18 | 19 | |
a1F/1F, 1S/1F, and 1F/2 genotypes
b1S/1F, 1S/1S, and 1S/2 genotypes
c1S/2, 1F/2, and 2/2 genotypes