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. Author manuscript; available in PMC: 2020 Feb 2.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Feb 2;139:116–138. doi: 10.1016/j.addr.2019.01.013

Fig. 1: Nanomaterial strategies to mitigate the immune response.

Fig. 1:

Chemical modification of host-interfacing polymers and encapsulants can provide specific functions including (starting top right, proceeding clockwise): tuning macrophage polarization by presentation of chemical structures including zwitterions, hydrophilic polymers, and polymer brushes; controlling factor (e.g. dexamethasone, curcumin, cyclosporine-A) release from nanoparticles; providing cytokine or factor (red) capture by peptide-recognition in functionalized hydrogels; enabling co-delivery of immunomodulatory molecules (e.g. biotin-streptavidin-FasL), not always requiring the use of an encapsulating hydrogel.