Table 1.
Renal Cell and Organ Stress- and Disease-related TSP1, CD47 and SIRP-α Expression
| Stress/Disease | Expression (protein, mRNA or immunoreactive) | ||
|---|---|---|---|
| TSP1 | CD47 | SIRP-α | |
| Stress: | |||
| Hypoxia | Increased | Increased | NK |
| TSP1 | NK | NK | Increased activity |
| Enalaparil | Increased | NK | NK |
| Ferric nitrilotriacetate | NK | Increased | NK |
| Mercuric chloride | Increased | NK | NK |
| LPS | NK | Increased | NK |
| Thy1.1 Ab | Increased | Increased | Decreased activity |
| Immune-associated | Increased in multiple diseases | NK | NK |
| Infection | NK | Decreased | NK |
| Metabolic (Diabetes) | Increased | Decreased | NK |
| eNOS deletion (low vascular NO) | Increased | NK | NK |
| Ureteral ligation | Increased | NK | NK |
| Non-renal transplant-related IRI: | |||
| Orthotopic liver transplant | Increased | NK | NK |
| Increased | Increased | Increased | |
| Renal vascular occlusion | |||
| Transplant-related IRI | Increased | NK | NK |
NK – Not Known