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. 2019 Jul 30;10(46):4786–4801. doi: 10.18632/oncotarget.27102

Table 5. Screening or prevention recommendations for persons carrying mutations of genes analyzed in the Cancer and Genetics Group panel (Adapted from [58]).

Gene Breast surveillance Risk reduction surgery Gynecologic surveillance
Breast Pelvis
BRCA1 BRCA2 30 - 65 year, annual MRI + mammogram (± Ultrasound) After 65 years, mammogram ± Ultrasound (Recommendations HAS 2014* and INCa 2017**) Prophylactic mastectomy (Recommendations HAS 2014 * and INCa 2017**) Prophylactic annexectomy (discussed from the age of 40 years and according to mutations and FH of OC) ** Before RRS: standard surveillance and no efficacious ovarian screening available *
PALB2 CDH1 No specific gynecological guidelines If FH of OC: MDC Standard surveillance
PTEN Standard surveillance If gynecologic lesions of CD: MDC
TP53 Starting at 20 years, annual MRI + Ultrasound (no systematic mammogram) Standard surveillance
RAD51C RAD51D No specific breast surveillance To be adapted to FH of BC according to guidelines HAS 2014* Not indicated Prophylactic annexectomy (discussed from the age of 45 years and according to FH of OC) Before RRS: standard surveillance and no efficacious ovarian screening to be proposed **
MLH1 MSH2 MSH6 PMS2 EPCAM Ovarian and/or uterine RRS To be discussed in MDC according to Lynch syndrome guidelines Uterine surveillance according to Lynch syndrome guidelines

BC: Breast Cancers; OC: Ovarian Cancers; FH: Family History; CD: Cowden disease; MDC: Multidisciplinary Committee; RRS: Risk reduction surgery.

*Recommendation of French Health Authority (HAS) 2014: French Breast cancer National screening program.

**©/Recommendation of French National Cancer Institute (INCa), April 2017.