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. 2019 Jul 5;6(8):ofz309. doi: 10.1093/ofid/ofz309

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© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Clinical symptoms in ferrets after inoculation with CB1/2014 severe fever with thrombocytopenia syndrome phlebovirus. Three ferrets were inoculated intramuscularly with 10^6.0 TCID₅₀ of virus, and direct contact (DC) and indirect contact (IC) ferrets (n = 6/group) were introduced into the cage at 2 dpi. Body temperature (A), relative weight (B), platelet count (C), and survival rate (D) were assessed and are shown as means with standard deviations. The number indicates a reduced number of samples collected due to death of ferrets in this group. Red, blue, and green symbols represent the direct infected, DC, and IC ferrets, respectively. Data are presented with the horizontal dotted line as the minimum threshold values. The Mantel Cox method was used to assess survival. Asterisks indicate statistical significance between direct and indirect contact ferrets, as determined from the same dpi as in the 2-tailed, unpaired t test (*P < .05). This experiment was performed in 3 independent trials.