Table 3.
Associations between DXA measurements of body fat and incident type 2 diabetes (N = 3028)
| DXA measurement | Incident type 2 diabetes HR (95% CI) | |
|---|---|---|
| Women (185 cases) | Men (137 cases) | |
| Android fat mass, %a | ||
| Model 1 | *1.77 (1.42, 2.22) | *1.43 (1.13, 1.81) |
| Model 2 | *1.42 (1.06, 1.89) | *1.44 (1.06, 1.95) |
| Model 3 | *1.36 (1.02, 1.82) | *1.41 (1.04, 1.92) |
| Model 4 | 1.22 (0.91, 1.64) | 1.32 (0.96, 1.83) |
| Model 5 | 1.10 (0.83, 1.46) | 1.33 (0.96, 1.85) |
| Gynoid fat mass, %a | ||
| Model 1 | 1.01 (0.76, 1.35) | 1.21 (0.91, 1.59) |
| Model 2 | *0.56 (0.40, 0.78) | 1.03 (0.74, 1.44) |
| Model 3 | *0.57 (0.41, 0.79) | 1.03 (0.74, 1.44) |
| Model 4b | *0.63 (0.45, 0.89) | 1.12 (0.78, 1.59) |
| Model 5 | 0.76 (0.54, 1.07) | 1.08 (0.76, 1.55) |
| Android to gynoid fat ratioa | ||
| Model 1 | *1.95 (1.55, 2.46) | *1.56 (1.16, 2.11) |
| Model 2 | *1.73 (1.36, 2.22) | *1.49 (1.09, 2.04) |
| Model 3 | *1.69 (1.32, 2.17) | *1.46 (1.06, 1.99) |
| Model 4 | *1.51 (1.16, 1.97) | 1.26 (0.91, 1.76) |
| Model 5 | 1.28 (0.98, 1.67) | 1.32 (0.93, 1.88) |
| Total fat mass, %a | ||
| Model 1 | *1.56 (1.17, 2.08) | *1.43 (1.11, 1.84) |
| Model 2 | 0.77 (0.53, 1.11) | *1.43 (1.00, 2.04) |
| Model 3 | 0.75 (0.52, 1.08) | 1.41 (0.98, 2.02) |
| Model 4b | 0.76 (0.52, 1.13) | 1.45 (0.99, 2.12) |
| Model 5 | 0.86 (0.59, 1.26) | 1.45 (0.99, 2.12) |
HRs are presented per 1 SD increase in the marker
Model 1, adjusted for age and cohort; model 2, additionally adjusted for BMI; model 3, additionally adjusted for systolic BP, treatment for hypertension, smoking and prevalent CVD; model 4, additionally adjusted for HDL-cholesterol, TG and serum lipid-reducing agents; model 5, additionally adjusted for FPG
aMarker is loge transformed
bp value from the interaction test for the difference in HR between women and men <0.05
*p<0.05, by Cox proportional hazards model