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. 2019 Aug 2;10:3486. doi: 10.1038/s41467-019-11477-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The m7 and m8 genes contribute to SOP selection. a Dorsal thorax of an E(spl)m7-m8/Df(3)P11 fly, lacking the m7 and m8 genes and carrying one copy of the mγ-m5 genes. An increase in bristle density (+35%) was observed. The m7 and m8 genes are required for the proper spacing of SOPs within a stripe but are dispensable for stripe patterning. b, c The expression of the m5 gene (smiFISH probe, green) was significantly upregulated in proneural stripes 1,3 and 5, at 8 h apf, in E(spl)m7-m8 mutant pupae (c) relative to wild-type controls (b; ac probe, red). d, e Adult flies with clones of cells homozygous for the E(spl)32.2 deletion, i.e., lacking all E(spl)-C genes, show patches of tufted bristles (d), whereas clones of Df(3L)mδ-m6 mutant cells display increased bristle density (e). This indicates that the m7 and m8 genes are sufficient for the singling out of SOPs. Scale bar is 10 μm (b: b, c)