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. 2019 Aug 2;9:11231. doi: 10.1038/s41598-019-47755-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NOVA1 expression after transfection of plasmid p1321 HPV-16 E6/E7. (A) In Western blot analysis, NOVA1 protein expression was detected in FaDu cells, but not in CAL27 cells. Transfection of HPV type 16 E6/E7 genes into FaDu and CAL27 did not induce a significant change in NOVA1 protein expression. (B) Generally, no significant changes in NOVA1 mRNA expression were observed upon transfection of HPV-16 E6/E7 genes into FaDu and CAL27 cells; a slight increase in mRNA was noted after 24 hours of transfection into FaDu cells. Fold changes in NOVA1 mRNA values were calculated based on NOVA1 levels of FaDu-CTR at 24 h and 48 h. Compared to NOVA1 mRNA levels in FaDu cells, those in CAL27 cells were very low. (CTL, controls with transfected empty vector; pHPV, cells with transfected plasmid HPV-16 E6/E7).