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. 2019 Aug 2;9:11231. doi: 10.1038/s41598-019-47755-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of miR-146 and NOVA1 in tumor cells and microenvironment cells from HNSCC tissue samples. (A) Expression of miR-146 in tumor areas (T) and stromal areas (S) of HNSCC tissue samples (n = 50). General expression levels of miRs, especially miR-146a, were higher in tumor areas than in stromal areas. (B) Levels of miR-146 in tumor and stroma areas were positively correlated. (C) Attenuated NOVA1 expression, reflected as an H-score < 200, indicating loss of NOVA1 in more than one-third of cells, were more frequently observed in tumor cells than in lymphocytes and stromal spindle cells. (D) Generally, tumor NOVA1 expression status was correlated with that of T lymphocytes and stromal spindle cells (P < 0.001, respectively).