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. 2019 Aug 2;9:11231. doi: 10.1038/s41598-019-47755-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Microenvironment Cell Populations-counter analysis. Z-score transformed values of log2 (normalized rsem + 1) values of genes and MCP-counter values were used to identify differences between groups for cell type abundance, inflammation-related genes, and EMT-related genes. Lower quantities of immune cells and stromal cells, downregulation of CD8+ T cell-related genes, and upregulation of SNAI2 and TGFB1 were related to low NOVA1 expression.