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. 2019 Aug 2;9:11277. doi: 10.1038/s41598-019-47653-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The developing eye at E12 was imaged at a low magnification (×724 K) and images stitched together to show the developing lens epithelium (LE), lens fibres (LF), surface ectoderm (SE), mesenchymal cells (MC) and inner layer of the optic cup (IOC). (A) Reconstructions within the area of the black box were made following the method described in Fig. 1. (A,B) The reconstructions showed all cells in the developing corneal stroma to be in close proximity to one another, appearing to indicate a condensation of cells. (B,C) To see the cell reconstructions in more detail, please refer to Supplementary Video 2.