Fig. 6.

S. pneumoniae impairs inflammasome activation via SpxB-mediated H₂O₂ release. a Schematic diagrams of the experimental setups used in (b). b ASC oligomers, Caspase-1 and IL-1β processing in LPS-primed BMDMs pre-treated with S.p. WT (D39, MOI 100) in the presence of catalase (100 U mL⁻¹) for 30 min before ATP stimulation (5 mM, 30 min) or P.a. infection (MOI 20, 60 min). c Schematic diagrams of the experimental setups used in d. d ASC oligomers, Caspase-1 and IL-1β processing in BMDMs pre-treated with 50 µM H₂O₂ for 10 min prior to stimulation with ATP (5 mM, 30 min) or infection with P.a. (60 min, MOI 20). The data in b and d are representative of three independent experiments. Source data are provided as a Source Data file