TABLE 1.
MICs for amidohydrolase mutantsa
| Strain | MIC (μg/ml) |
|||
|---|---|---|---|---|
| FOX | CTX | CAZ | FEP | |
| S. marcescens ATCC 13880 | 16 | 0.13 | 0.25 | 0.06 |
| S. marcescens ATCC 13880 ΔampD | 16 | 0.13 | 0.25 | 0.03 |
| S. marcescens ATCC 13880 ΔamiD | 16 | 0.13 | 0.25 | 0.13 |
| S. marcescens ATCC 13880 ΔamiD2 | 16 | 0.25 | 0.50 | 0.13 |
| S. marcescens ATCC 13880 ΔampD ΔamiD | 16 | 0.50 | 0.25 | 0.13 |
| S. marcescens ATCC 13880 ΔampD ΔamiD2 | 16 | 2.00 | 0.50 | 0.25 |
| S. marcescens ATCC 13880 ΔamiD ΔamiD2 | 16 | 0.13 | 0.25 | 0.06 |
| S. marcescens ATCC 13880 ΔampD ΔamiD ΔamiD2 | 16 | 2.00 | 0.50 | 0.25 |
a
MICs were calculated using broth microdilution according to CLSI guidelines. FOX, cefoxitin; CTX, ceftriaxone; CAZ, ceftazidime; FEP, cefepime.