Table 4.
Therapy efficacy
| TNFi treatment (n = 103) Mean ± SD |
No TNFi treatment (n = 47) Mean ± SD |
Difference | |
|---|---|---|---|
| BASDAI | 3.23 ± 1.67 | 5.26 ± 1.96 | p < 0.00001 |
| Axial pain | 3.67 ± 1.92 | 6.04 ± 2.26 | p < 0.00001 |
| Peripheral joints pain/swelling | 2.79 ± 2.08 | 4.45 ± 2.75 | p = 0.00021 |
| Enthesitis | 2.53 ± 2.00 | 3.75 ± 2.85 | p = 0.00957 |
| Morning stiffness duration | 3.02 ± 2.07 | 6.04 ± 3.44 | p < 0.00001 |
| Morning stiffness level | 3.23 ± 1.94 | 6.04 ± 2.73 | p < 0.00001 |
| Fatigue | 4.01 ± 2.15 | 6.04 ± 2.33 | p < 0.00001 |
| ASDAS | 2.16 ± 0.94 | 3.41 ± 0.99 | p < 0.00001 |
| Patient global assessment | 3.37 ± 1.84 | 5.85 ± 2.42 | p < 0.00001 |
| BASFI | 2.92 ± 2.04 | 4.08 ± 2.28 | p = 0.00381 |
| Putting on socks | 2.39 ± 2.43 | 3.89 ± 3.04 | p = 0.00521 |
| Bending forward | 3.45 ± 2.64 | 4.92 ± 3.17 | p = 0.00643 |
| Reaching up | 2.52 ± 2.50 | 3.51 ± 3.22 | NS |
| Getting up from a chair | 2.36 ± 2.79 | 3.53 ± 3.22 | p = 0.04035 |
| Getting up off the floor from lying | 3.10 ± 2.44 | 5.11 ± 2.71 | p = 0.00003 |
| Standing unsupported | 3.15 ± 3.01 | 4.23 ± 3.09 | p = 0.04894 |
| Climbing 12–15 steps | 2.30 ± 2.60 | 3.32 ± 3.12 | NS |
| Looking over your shoulder | 4.35 ± 3.25 | 5.40 ± 3.18 | NS |
| Doing physically demanding activities | 3.57 ± 2.45 | 4.87 ± 3.13 | p = 0.01057 |
| Doing a full day activities | 2.01 ± 1.94 | 2.04 ± 2.59 | NS |
| ESR | 14.33 ± 15.69 | 24.53 ± 23.95 | p = 0.00692 |
| CRP | 10.39 ± 26.69 | 13.54 ± 13.59 | p < 0.00001 |
| Remission or low disease activity number (%) | 56 (54.37%) | 5 (10.64%) | p < 0.00001 |
ASDAS Ankylosing Spondylitis Disease Activity Score, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, NS not significant, TNFi TNF inhibitors