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Conformations of CDR H3s. (A) B4 Fab. (B) B13 Fab. In both (A) and (B) HC is coloured in red and LC in blue. The disulphides are shown as orange sticks (note C100E is Kabat numbering). Surface charge profiles of the variable domains of B4 Fab (C) and B13 Fab (D) viewed from the top. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
