Fig. 6.

The effects of LC on the structure of HC. (A) Structural differences between B4 H3 and B4* H3. B4 HC is in red and B4 LC in blue, B4* is in grey. The running directions of H3s are indicated by arrows. (B) Structural differences between the H3s of B13 (red and blue) and B13* (grey). Side chains and disulphides are shown as sticks. Residues are shown in Kabat numbering. For the light chains the final letter is in brackets and represents the one letter code for the sequence of the hybrid Fab (in all cases the letter preceding the residue represents the amino acid of the native Fab). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)