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. 2019 Jul 31;4(4):e000527. doi: 10.1136/esmoopen-2019-000527

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© Author (s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Change from baseline in NRS scores in patients with possible disruption (A) or without possible disruption (B) to BBB (LS mean; error bars are 95% CI) (safety analysis set). BBB, blood–brain barrier; BL, baseline; LS, least squares; NRS, Numerical Rating Scale.