Table 4.
Primary and secondary outcomes—all performed by blinded assessors*
| Instrument | Assessment timing | |
| Primary outcome | ||
| Physical functioning | 6 min walk distance (6MWD) | Hospital discharge |
| Secondary outcomes | ||
| Overall strength-upper and lower extremity | MRC sum-score | Hospital discharge |
| Quadriceps force-lower extremity strength | Hand-held dynamometry | Hospital discharge |
| Distal strength-hand grip strength | Hand grip dynamometry | ICU and hospital discharge |
| Overall Physical Functional status | SPPB and FSS-ICU | ICU and hospital discharge |
| Physical functioning (ADL) | Katz ADL | Hospital discharge |
| Mortality | Chart review | ICU and hospital discharge |
| Length of ventilation, ICU and hospital stay | Chart review | ICU and hospital discharge |
| ICU readmission and reintubation | Chart review | Hospital discharge |
| Hospital-acquired infections | Chart review | Hospital discharge |
| Discharge location (eg, home vs rehab) | Chart review | Hospital discharge |
| Body composition | Ultrasound of rectus femoris, vastus intermedius, tibialis anterior | Enrolment, ICU and hospital discharge |
| Body composition (when clinically available) | Chest CT scan (above the aortic arch) | Only when clinically available |
| Body composition (when clinically available) | Abdominal CT scan at third lumbar vertebra | Only when clinically available |
| Health-related quality of life | SF-36 and EQ-5D-5L | Telephone survey at 6 months |
| Physical functioning | Katz ADL; Lawton IADL | Telephone survey at 6 months |
| Physical functioning | Return to baseline work/activity | Telephone survey at 6 months |
| Physical functioning | Living location | Telephone survey at 6 months |
| Mental and cognitive functioning | MoCA-BLIND, HADS and IES-R | Telephone survey at 6 months |
| Healthcare resource utilisation | Admission to ICU, hospital, rehabilitation and nursing facility | Telephone survey at 6 months |
ADL, activities of daily living; IADL, instrumental activities of daily living; FSS-ICU, Functional Status Score for ICU; ICU, intensive care unit; MRC, Medical Research Council; SPPB, Short Physical Performance Battery.