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. 2019 Jul 29;9(7):e029675. doi: 10.1136/bmjopen-2019-029675

Table 4.

Risk of comorbid mood and substance-related mental and behavioural disorders for children by level of child protection involvement

Characteristic Mood (affective) disorder* Substance-related mental and behavioural disorder† Mood and substance-related mental and behavioural disorder
Univariate Multivariate Univariate Multivariate Univariate Multivariate
HR (95% CI) HR (95% CI)‡ HR (95% CI) HR (95% CI)‡ HR (95% CI) HR (95% CI)‡
Child protection involvement§
 No Involvement Reference Reference Reference Reference Reference Reference
 Unsubstantiated allegation 3.18 (2.83 to 3.57) 2.21 (1.92 to 2.54) 3.92 (3.55 to 4.34) 1.92 (1.68 to 2.19) 4.54 (3.75 to 5.51) 2.52 (1.97 to 3.22)
 Substantiated allegation 3.81 (3.31 to 4.40) 2.56 (2.16 to 3.03) 4.23 (3.71 to 4.82) 1.95 (1.64 to 2.31) 6.45 (5.17 to 8.04) 3.60 (2.73 to 4.73)
 Substantiated allegation and entered out-of-home care 4.05 (3.38 to 4.86) 2.20 (1.75 to 2.77) 8.59 (7.54 to 9.77) 2.71 (2.26 to 3.26) 8.80 (6.86 to 11.29) 3.03 (2.14 to 4.31)
Substantiated allegation§
 No Reference Reference Reference Reference Reference Reference
 Yes 3.59 (3.20 to 4.03) 2.10 (1.82 to 2.43) 5.13 (4.66 to 5.65) 1.96 (1.71 to 2.23) 6.39 (5.38 to 7.58) 2.78 (2.19 to 3.53)
Characteristic Stress-related disorders* Substance-related mental and behavioural disorder† Stress and substance-related mental and behavioural disorder
Univariate Multivariate Univariate Multivariate Univariate Multivariate
HR (95% CI) HR (95% CI)‡ HR (95% CI) HR (95% CI)‡ HR (95% CI) HR (95% CI)‡
Child protection involvement§
 No involvement Reference Reference Reference Reference Reference  Reference
 Unsubstantiated allegation 3.75 (3.49 to 4.03) 2.61 (2.39 to 2.84) 3.62 (3.25 to 4.03) 1.83 (1.59 to 2.11) 5.14 (4.40 to 6.00)  2.54 (2.07 to 3.12)
 Substantiated allegation 4.72 (4.32 to 5.16) 3.23 (2.90 to 3.59) 3.98 (3.46 to 4.57) 1.86 (1.56 to 2.23) 6.48 (5.36 to 7.83)  3.34 (2.62 to 4.27)
 Substantiated allegation and entered out-of-home care 6.29 (5.70 to 6.94) 3.24 (2.85 to 3.69) 6.35 (5.43 to 7.41) 1.97 (1.60 to 2.44) 14.06 (11.81 to 16.75)  4.61 (3.57 to 5.94)
Substantiated allegation§
 No Reference Reference Reference Reference Reference  Reference
 Yes 4.82 (4.50 to 5.15) 2.67 (2.44 to 2.91) 4.35 (3.91 to 4.84) 1.68 (1.45 to 1.94) 7.90 (6.90 to 9.04)  3.12 (2.57 to 3.78)

*Excludes comorbid substance-related mental and behavioural disorders.

†Excludes mood (affective) disorders.

‡All other covariates included (aboriginality, gender, socioeconomic status, parent marital status at birth, maternal age at birth, paternal age at birth, maternal mental health (MH) contact, maternal substance-related contact, paternal MH contact, paternal substance-related contact).

§Separate Cox regression models, second model compares all children with substantiated allegations (including those who entered out-of-home care) to all children without substantiated allegations (including no contact or only unsubstantiated allegations).