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. 2019 Jul 31;9(7):e022877. doi: 10.1136/bmjopen-2018-022877

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Predicted long-term changes in BMI from long chain n-3 PUFAs intake according to FADS genotypes numbers of T carriers/Non-T carriers in the NHS and HPFS are 1698/9625 and 1025/5808, respectively. Black circles for T allele carriers and open circle for non-T-carriers. The multiple linear regression model was used to test the associations of long chain n-3 PUFAs intake with long-term changes in BMI according to FADS genotypes after adjustment for age, source of genotyping data, baseline BMI, smoking, alcohol intake, physical activity, total energy intake, alternate healthy eating index, television watching, sugar sweetened beverage, fried food consumption. The individual participant data from the NHS and HPFS cohorts were pooled. BMI, body mass index; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FADS, fatty acid desaturases gene; HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PUFA, polyunsaturated fatty acid; HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study.