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. 2018 Dec 22;56(8):521–525. doi: 10.1136/jmedgenet-2018-105700

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Pedigrees of MINAS patients. Filled quarters of symbols indicate affected patients (each color denotes a specific type of tumor). Current age, age at death and age at diagnosis, when available, are also detailed. Proband is marked by an arrow, carrier status was studied in available relatives, and those carrying the variant are shown with the variant symbol (#,$) and if genotyped and not carriers a (-) is under the mutation symbol. A number inside a symbol denotes the number of siblings condensed in the symbol. Brain C (light orange), BC: breast cancer (emerald), C pol: colon polyposis (light green), CRC: colorectal cancer (red), CUP: carcinoma of unknown primary (yellow), Kidney Cancer (black), Leiomyomas (light blue), Lymphoma (orange), Melanoma (brown), NET: neuroendocrine tumor (dark green), OC: ovarian cancer (blue), Tuberous sclerosis (purple), UC: uterine carcinoma (pink).