Table 2.

CLDRC multivariate replication

Marker	CHR	BP	Minor allele	MAF*	P value
					Joint model	RAN Pictures	RAN Colours	RAN Letters	RAN Numbers
rs6963842†	7	107 634 989	T	0.495	0.360	0.963	0.644	0.856	0.244
rs1555839†	10	90 382 820	C	0.319	0.018	0.256	0.019	2.38×10−3‡	0.086
rs701825†	10	90 417 547	G	0.282	4.60×10−3‡	0.562	4.09×10−3‡	9.32×10−4‡	0.04

Results from the joint analysis of RAN Colours, RAN Pictures, RAN Letters and RAN Numbers across the top associated markers from the GRaD multivariate and meta-analytic discovery analyses. Results from follow-up, independent univariate analysis of RAN Pictures, RAN Colours, RAN Letters and RAN Numbers at each marker are also represented.

*MAF based on allele frequencies within the CLDRC sample.

†Imputed markers.

‡Survives Bonferroni correction for multiple testing (p<0.05/3=0.0161).

BP, base position; CHR, chromosome; CLDRC, Colorado Learning Disability Research Center; GRaD, Genes, Reading, and Dyslexia study; MAF, minor allele frequency; RAN, rapid automatised naming.