Table 3.
Molecular profile of serrated colorectal lesions.
| Serrated Lesion | BRAF/KRAS Status | CIMP Rate | Gene Methylation | MSI Rate |
|---|---|---|---|---|
| HP | BRAF mutated | CIMP-H | MLH1 not methylated | MSS |
| MPHP * | controversial | CIMP-H | controversial | controversial |
| GCHP * | KRAS mutated | CIMP-L | MLH1 not methylated | MSS |
| MVHP * | BRAF mutated | CIMP-H | MLH1 not methylated | MSS |
| SSA/P | BRAF mutated | CIMP-H | MLH1 not methylated | MSS |
| SSAD | BRAF mutated | CIMP-H | MLH1 hypermethylated | MSI |
| TSA | KRAS/BRAF mutated or neither | CIMP-L/-H | MLH1 not methylated | MSS |
| TSA HGD | KRAS mutated | CIMP-L | MGMT hypermethylated | MSS |
* MPHP, GCHP, MVHP are HP subtypes.