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ESR1 fusion genes detected in patients with ETR breast cancers. The exons (e1–e10) of the ESR1 gene and the domain structure of ERα are shown. The fusion of e2 and e6 to the indicated partners and the impact of individual fusion products on ETR and ER transcriptional activity are provided. AF1: activation function 1 domain; DBD: DNA-binding domain; Hinge: hinge region; AF2/LDB: activation function 2/ligand-binding domain; +: enhancement; NA: not available.
