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. 2019 Jul 9;8(7):997. doi: 10.3390/jcm8070997

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Clinical trial design proposal for a risk-driven personalized approach. NDMM: newly-diagnosed MM. RRMM: relapsed-refractory MM. ASCT: autologous stem cell transplantation. Allo-SCT: allogeneic stem cell transplantation. MRD: minimal residual disease. * FISH, NGS (genomic panels including known actionable mutation and TP53 mutation), and GEP. ** FISH, NGS (genomic panels including known actionable mutation and TP53 mutation and drug resistance-related genomic alterations), and GEP. CAR-T: Chimeric Antigen Receptor T cell; BiTE: Bispecific T cell engager antibody; tandem ASCT: double autologous stem cell transplantation. Tandem ASCT is already being investigated in experimental studies.