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. 2019 Jul 17;20(14):3502. doi: 10.3390/ijms20143502

Figure 5.

Figure 5

Genetic deletion of Ephx2 or pharmacological inhibition of sEH prevented IR-induced activation and translocation of the pro-oxidant Txnip. Representative immunoblots and densiometric quantification of protein expression of (A) cytosolic Txnip and (B) mitochondrial Txnip in hearts after 30 min ischemia and 40 min reperfusion. Cytosolic protein expression was normalized to GAPDH while mitochondrial Txnip expression was normalized to Hsp60. Values represent mean ± SEM, * p < 0.05 vs. WT Aerobic CT, ☨ p < 0.05 vs. sEH null Aerobic, # p < 0.05 vs. WT IR (n = 3–4 per group).