Table 2.

Overview of mitophagy or mitochondrial dynamics deficits in PD transgenic models. Overexpression or deficiency of PD-related genes, including SNCA, PRKN, PINK1, DJ-1, LRRK2, and GBA, contributes to mitophagy or defects in mitochondrial dynamics. α-syn, α-synuclein; DA, dopaminergic; GBA, glucocerebrosidase; LRRK2, Leucine-rich repeat kinase 2; PINK1, PTEN-induced putative kinase 1.

Gene	Model	Motor Deficits	Loss of DA Neurons	α-syn Pathology	Mitophagy Defect	Mitochondrial Dynamics Defect
SNCA	Wide-type α-syn overexpression	+	+	+	+	+
	A53T α-syn overexpression	+	+	+	+	+
	A30P α-syn overexpression	+	+	+	-	-
PRKN	Parkin deficiency	-	-	-	+	+
PINK1	PINK1 deficiency	-	-	-	+	+
DJ-1	DJ-1 deficiency	+	-	-	+	+
LRRK2	G2019S LRRK2 overexpression	+	+	-	+	+
GBA	L1444P GBA overexpression	+	unknown	+	+	+
	GBA deficiency	+	unknown	+	+	+