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Serum resistance. In vitro evidence supports that A. actinomycetemcomitans outer membrane proteins, Omp100 and OmpA1, may allow trapping of soluble repressors of complement activation, i.e., Factor H and C4 binding protein (C4bp), respectively. This would result in downregulation of the alternative, classical, and mannose-binding lectin (MBL) pathway of complement activation.
