Table 1.
Mammalian epigenetic modifiers.
| Function | Enzyme (Alias) | |
|---|---|---|
| DNA methyltransferase | DNMT1 | DNMT3B |
| DNMT2 | DNMT3L | |
| DNMT3A | ||
| DNA demethylases | TET1 | |
| TET2 | ||
| TET3 | ||
| Histone methyltransferase | KMT1A (SUV39H1) | KMT3E (SMYD3) |
| KMT1B (SUV39H2) | KMT3F (NSD3) | |
| KMT1C (EHMT2) | KMT3G (NSD2) | |
| KMT1D (EHMT1) | KMT4 (DOT1L) | |
| KMT1E (SETDB1) | KMT5A (SETD8) | |
| KMT1F (SETDB2) | KMT5B (SUV420H1) | |
| KMT2A (MLL) | KMT5C (SUV420H2) | |
| KMT2B (MLL2) | KMT6A (EZH2) | |
| KMT2C (MLL3) | KMT6B (EZH1) | |
| KMT2D (MLL4) | KMT7 (SETD7) | |
| KMT2E (MLL5) | KMT8A (PRDM2) | |
| KMT2F (SETD1A) | KMT8B (PRDM9) | |
| KMT2G (SETD1B) | KMT8C (PRDM6) | |
| KMT2H (ASH1L) | KMT8D (PRDM8) | |
| KMT3A (SETD2) | KMT8E (MECOM) | |
| KMT3B (NSD1) | KMT8F (PRDM16) | |
| KMT3C (SMYD2) | SMYD4 (ZMYND21) | |
| KMT3D (SMYD1) | ||
| Histone demethylase | KDM1A (LSD1) | KDM5B (JARID1B) |
| KDM1B (LSD2) | KDM5C (JARID1C) | |
| KDM2A (FBXL11) | KDM5D (JARID1D) | |
| KDM2B (FBXL10) | KDM6A (UTX) | |
| KDM3A (JMJD1A) | KDM6B (JMJD3) | |
| KDM3B (JMJD1B) | KDM6C (UTY) | |
| KDM3C (JMJD1C) | KDM7A (JHDM1D) | |
| KDM4A (JMJD2A) | KDM7B (PHF8) | |
| KDM4B (JMJD2B) | KDM7C (PHF2) | |
| KDM4C (JMJD2C) | KDM8 (JMJD5) | |
| KDM4D (JMJD2D) | JMJD6 | |
| KDM4E (JMJD2E) | PADI4 | |
| KDM4F (JMJD2F) | NO66 | |
| KDM5A (JARID1A) | ||
| Histone acetyltransferase | KAT1 (HAT1) | KAT7 (HBO1, MYST2) |
| KAT2A (GCN5) | KAT8 (hMOF, MYST1) | |
| KAT2B (PCAF) | KAT9 (ELP3) | |
| KAT3A (CREBBP) | KAT12 (GTF3C4) | |
| KAT3B (EP300) | KAT13A (NCOA1) | |
| HAT4 (NAA60) | KAT13B (NCOA3) | |
| KAT4 (TAF1) | KAT13C (NCOA2) | |
| KAT5 (TIP60) | KAT13D (CLOCK) | |
| KAT6A (hMOZ, MYST3) | KAT14 (CRP2BP) | |
| KAT6B (hMORF, MYST4) | MCM3AP (GANP) | |
| Histone deacetylase | HDAC1 | HDAC10 |
| HDAC2 | HDAC11 | |
| HDAC3 | SIRT1 | |
| HDAC4 | SIRT2 | |
| HDAC5 | SIRT3 | |
| HDAC6 | SIRT4 | |
| HDAC7 | SIRT5 | |
| HDAC8 | SIRT6 | |
| HDAC9 | SIRT7 | |