Table 2.

Maximum number (N_max) of proteins adsorbed over the AuNP calculated by means of Coarse-Grained simulations (CG) and equations provided by Wang et al. [28], by Calzolai et al. [29] and by Dell’Orco et al. [30].

Model	Protein
	MB	HB	TRP
Wang et al. [28] *	84	35	76
Calzolai et al. [29] †	80	52	75
Dell’Orco et al. [30] ‡	25	10	22
This work CG (equation 1)	46 ± 5	18 ± 2	63 ± 5

* $N^{max}=\frac{4R_{AuNP}^2}{R_G^2}$, where N_max is the Maximum Number of Proteins, RG is the radius of gyration of the proteins (R_G(MB) = 16.39, R_G(HB) = 25.30, R_G(TRP) = 17.19), R_AuNP is the radius of the nanoparticle determined experimental measurements. † $N_{max}=\frac{0.65\left[{\left(R_{AuNP}+2R_{Prot}\right)}^3-R_{AuNP}^3\right]}{R_{Prot}^3},$ where (R_AuNP + 2R_Prot) is the radius of the AuNP-protein corona complex, R_AuNP is the radius of AuNP, and R_Prot is the radius of the protein. ‡$N_{max}=4 \times \pi \frac{\left[{\left(R_{AuNP}-R_{Prot}\right)}^2\right]}{\pi ·R_{Prot}^2}$.