Table 4.
Adjusted OR for the independent association of physical activity with abnormal levels * of ALT and AST among participants with NAFLD (n = 6968).
| Inactive | Minimally Active | HEPA Active | p for Trend † | |
|---|---|---|---|---|
| Abnormal ALT | ||||
| Model 1 | 1.0 | 1.0 (0.8–1.1) | 0.8 (0.7–0.9) | 0.013 |
| Model 2 | 1.0 | 1.0 (0.8–1.1) | 0.8 (0.7–0.9) | 0.020 |
| Model 3 | 1.0 | 1.0 (0.8–1.1) | 0.8 (0.6–0.9) | 0.007 |
| Model 4 | 1.0 | 1.0 (0.8–1.2) | 0.8 (0.6–0.9) | 0.007 |
| Model 5 | 1.0 | 1.0 (0.8–1.1) | 0.8 (0.6–0.9) | 0.006 |
| Abnormal AST | ||||
| Model 1 | 1.0 | 0.9 (0.8–1.1) | 0.9 (0.8–1.1) | 0.621 |
| Model 2 | 1.0 | 0.9 (0.8–1.1) | 0.9 (0.8–1.1) | 0.652 |
| Model 3 | 1.0 | 0.9 (0.8–1.1) | 0.9 (0.7–1.1) | 0.409 |
| Model 4 | 1.0 | 0.9 (0.8–1.1) | 0.9 (0.7–1.1) | 0.451 |
| Model 5 | 1.0 | 0.9 (0.8–1.1) | 0.9 (0.7–1.1) | 0.427 |
Values are the OR (95% CI). * Defined as >34 IU/L in men or >24 IU/L in women for ALT and >32 IU/L in men or >26 IU/L in women for AST. † p values by complex-samples logistic regression model. Model 1 adjusted for age and sex. Model 2, adjusted for model 1 plus BMI. Model 3, adjusted for model 2 plus total calorie intake, sleep duration, smoking, alcohol, education level. Model 4, adjusted for model 3 plus diabetes mellitus, cardiovascular disease, hypertension, arthritis. Model 5, adjusted for model 4 plus central obesity. OR, odds ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; NAFLD, non-alcoholic fatty liver disease; HEPA, health-enhancing physical activity; BMI, body mass index.