TAD |
transactivation domain |
DBD |
DNA binding domain |
OD |
oligomerization domain |
SAM |
sterile alpha motif |
TID |
transcriptional inhibitory domain |
WT |
wild type |
HNSCC |
head and neck squamous cell carcinoma |
miRNA |
microRNA |
lncRNA |
long non-coding RNA |
SA-β-gal |
senescence-associated β-galactosidase |
HDAC |
histone deacetylase |
BMP |
bone morphogenetic protein |
SHH |
sonic hedgehog |
FGFR2 |
fibroblast growth factor receptor 2 |
TGF-β |
transforming growth factor β |
EDC |
epidermal differentiation complex |
EEC |
Ectrodactyly Ectodermal Dysplasia-Clefting Syndrome |
AEC |
Ankyloblepharon-Ectodermal Dysplasia Clefting Syndrome |
SCC |
squamous cell carcinoma |
TCGA |
The Cancer Genome Atlas |
cSCC |
cutaneous squamous cell carcinoma |
ChIP-Seq |
chromatin immunoprecipitation-sequencing |
EGFR |
epidermal growth factor receptor |
MAPK |
mitogen-activated protein kinase |
FGF |
fibroblast growth factor |
EMT |
epithelial-mesenchymal transition |
iASPP |
inhibitor of apoptosis-stimulating protein of p53 |
CSC |
cancer stem cell |
HK2 |
hexokinase 2 |
ROS |
reactive oxygen species |
GPX2 |
glutathione peroxidase 2 |
PAI-2 |
plasminogen activator inhibitor-2 |
TIMP |
tissue inhibitor of metalloproteinase |
MT1-MMP |
membrane-type 1-matrix metalloproteinase |
MMP |
matrix metalloproteinase |