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. 2019 Jul 17;11(7):994. doi: 10.3390/cancers11070994

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Farnesyl pyrophosphate (FPP) and gernaylgerany parophosphate (GGPP) have a cell line-specific response in medulloblastoma cell lines. Both FPP and GGPP levels were significantly reduced in Daoy cells compared to D283 (A,B) and D341 cells (C,D) when treated with simvastatin (5 µM) at 96 h. However, GGPP was observed to be significantly higher in D341 cells, when compared to Daoy cells, even under non-treatment conditions. Unlike Daoy versus D283 and D341, both FPP and GGPP levels remain unchanged between D283 and D341 under non-treatment conditions. Only GGPP was significantly reduced in D283 cells compared to D341 cells (E,F) when treated with simvastatin. Statistical significance was reported by two-way ANOVA using GraphPad Prism 6.0. p-value is reported as **** p < 0.0001, *** p < 0.001, or ** p < 0.01. Data are expressed as means ± SEM, and n = 15.

Farnesyl pyrophosphate (FPP) and gernaylgerany parophosphate (GGPP) have a cell line-specific response in medulloblastoma cell lines. Both FPP and GGPP levels were significantly reduced in Daoy cells compared to D283 (A,B) and D341 cells (C,D) when treated with simvastatin (5 µM) at 96 h. However, GGPP was observed to be significantly higher in D341 cells, when compared to Daoy cells, even under non-treatment conditions. Unlike Daoy versus D283 and D341, both FPP and GGPP levels remain unchanged between D283 and D341 under non-treatment conditions. Only GGPP was significantly reduced in D283 cells compared to D341 cells (E,F) when treated with simvastatin. Statistical significance was reported by two-way ANOVA using GraphPad Prism 6.0. p-value is reported as **** p < 0.0001, *** p < 0.001, or ** p < 0.01. Data are expressed as means ± SEM, and n = 15.