Table 2.

Frequency of REL gene locus amplifications in human B cell lymphoma subtypes. The frequencies of amplifications are displayed. Studies summarized in Table 1 were included in this table if amplifications were defined as a REL copy number of ≥4 copies or REL gene ratio of ≥2. In parenthesis, the fraction of the total number of investigated patients is given. The average percentage of REL amplification per subtype (bold, last row) was calculated using the sum of total reported patient numbers, the average for DLBCL includes data from both GCB- and ABC-DLBCL subgroups. *¹ aCGH results distinguishing gains and amplifications only provided for 15 paired FL/tFL samples. Part of the total patient panel was additionally analyzed by qPCR. *² Jardin et al. [128] did not distinguish gains/amplifications but provided gene ratios for all samples. Numbers presented here are based on a REL gene ratio of ≥2 representing amplifications. For additional information on studies and provided numbers as well as method abbreviations see legend of Table 1.

Reference	Method	FL	tFL	DLBCL	GCB-DLBCL	ABC-DLBCL	PMBCL	cHL
Martinez-Climent et al. [110]	aCGH	0% (0/10)	20% (2/10)
Pasqualucci et al. [112]	WES, SNP array	8% (1/12)	8% (1/12) 31% (12/39)
Kwiecinska et al. [113] *1	aCGH, qPCR	7% (1/15)	20% (3/15)
Bouska et al. [114]	SNP array	10% (19/198)	13% (10/79)
Houldsworth et al. [89] Rao et al. [90]	SB			23% (26/111)
Jardin et al. [128] *2	QMPSF			4% (1/23)	7% (2/27)	2% (1/64)
Rosenwald et al. [94]	qPCR				15% (17/115)	0% (0/73)
Houldsworth et al. [77]	SB				28% (5/18)	17% (2/12)
Feuerhake et al. [101]	qPCR				17% (10/57)	5% (1/22)	3% (1/34)
Joos et al. [119]	CGH						8% (2/26)
Bentz et al. [121]	CGH						0% (0/43)
Weniger et al. [122]	FISH						25% (5/20)
Palanisamy et al. [120]	SB						36% (4/11)
Martin-Subero et al. [83]	FICTION							26% (8/31)
Joos et al. [125]	CGH							2% (1/41)
Barth et al. [36]	CGH, FICTION							12% (2/17)
Salipante et al. [127]	WGS							30% (6/20)
Average		9%	18%	12%	16%	2%	9%	16%